Fiehn BIS103 lecture 09_fall 2010

Fiehn BIS103 lecture 09_fall 2010 - Glycogen metabolism...

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1 Glycogen metabolism Glycogen
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2 Glycogen metabolism: separate pathways for synthesis and breakdown Glycosylation (glycogen synthesis) ATP + UDP bB UTP + ADP Glycogenin initiates glycogen synthesis UDPG + B gluc BB gluc 7 G G G
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3 Glycosylation (glycogen synthesis) Glycogen synthesis
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4 Glycogen structure is determined by branching enzyme Glycogen breakdown is performed by Phosphorylase Vitamin B 6 derivative covalently bound by Schiff base (imine) Glycogen breakdown 1. Glycogen phosphorylase n glycogen + P i b n -1 glycogen + G1P 2. Glycogen debranching enzyme 3. Phosphoglucomutase G1P Bb G6P
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5 Primary glycogen breakdown by Phosphorylase Further glycogen breakdown by debranching enzyme
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6 Final glycogen breakdown by Phosphoglucomutase Reverse of glycolysis hexokinase G6P b glucose by Glucose-6-Phosphatase G6Pase in the liver ER involves specific translocase and transporters back to cytosol for glucose and Pi Glycogen breakdown/synthesis: flux control by allosteric regulation activation AMP inactivation G6P, ATP activation G6P, ATP inactivation AMP
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Fiehn BIS103 lecture 09_fall 2010 - Glycogen metabolism...

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