Fiehn BIS103 lecture 11_fall 2010

Fiehn BIS103 lecture 11_fall 2010 - in one single large...

Info iconThis preview shows pages 1–14. Sign up to view the full content.

View Full Document Right Arrow Icon
1 Use of acetyl-CoA in liver (by TCA cycle oxidation and) by ketogenesis forming ketone bodies Ketogenesis in liver -CO 2 acetone β -hydroxybutyrate acetoacetate NAD + NADH + H +
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
2 Use of β -hydroxybutyrate as fuel Diabetes is a metabolic disorder
Background image of page 2
3 Lipid biosynthesis Fatty acid degradation and synthesis are spatially separated
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
4 Lipid biosynthesis Acetyl-CoA enters the cytosol via the citrate shuttle
Background image of page 4
5 α -Acetyl-CoA carboxylase (ACC) is committing acetyl-CoA for fatty acid biosynthesis Biotin carrier protein Transcarboxylase Biotin carrier protein Biotin carboxylase Acetyl-CoA The fatty acid synthase complex consists of 7 enzymes
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
6 The fatty acid synthase complex consists of 7 enzymes The acyl carrier protein ACP uses phosphopantetheine as prosthetic group
Background image of page 6
7 Fatty acid biosynthesis involves four repetitive reactions reduction 4 NADP + NADPH + H + dehydration 3 - H 2 O KS β -ketoacyl-ACP synthase KR β -ketoacyl-ACP reductase ER enoyl-ACP reductase DH β -hydroxyacyl-ACP dehydratase Thioesterase releases the C16 fatty acid
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
8 The fatty acid synthase complex may be formed
Background image of page 8
Background image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 10
Background image of page 11

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 12
Background image of page 13

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 14
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: in one single large enzyme The location of fatty acid synthesis differs between plant and animal cells 9 Energy balance of fatty acid biosynthesis Activation 7 acetyl-CoA + 7 CO 2 + 7 ATP b 7 Malonyl-CoA + 7 ADP +7 P i Biosynthesis (7 rounds) Acetyl-CoA + 7 Malonyl-CoA + 14 NADPH b Palmitoyl-CoA + 7 CO 2 + 7 CoASH + 14 NADP + + 7 H 2 O Sum 8 Acetyl-CoA + 7 ATP + 14 NADPH b C16:0 + 8 CoASH + 6 ADP + 6 P i + 14 NADP + + 6 H 2 O Fatty acid elongation 10 Fatty acid desaturation Longer and unsaturated fatty acids 11 Essential fatty acids Arachidonic acid is an important precursor for mammalian hormones 12 The liver is the organ of lipid metabolism Biosynthesis of TAG and membrane lipids 13 2x Glycerol-3P is the precursor for membrane lipids and TAG Phosphatidic acid is the branch point for membrane lipids and TAG 14 Two strategies for membrane head groups Examples P~glcyerol-3P, P~serine, P~ethanolamine, P~choline PS decarboxylase methyltransferase...
View Full Document

This note was uploaded on 01/08/2011 for the course BIS 103 taught by Professor Abel during the Winter '08 term at UC Davis.

Page1 / 14

Fiehn BIS103 lecture 11_fall 2010 - in one single large...

This preview shows document pages 1 - 14. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online