Fiehn BIS103 lecture 12_fall 2010

Fiehn BIS103 lecture 12_fall 2010 - Secondary metabolism is...

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1 Secondary metabolism • is a historic name for metabolites that did not seem vital or essential compared to primary metabolites • more than 200,000 compounds are known (in plants and microorganisms), i.e. ‘secondary metabolites’ comprise >99% of these. Many are lipophilic. • many secondary metabolites are not conserved across species but play important roles in chemical communication and defense (of plants and microbes) and may be used for other purposes in mammalians. • during evolution, certain ‘secondary metabolites’ were turned into very vital cofactors or oxidative protectants in mammalians, such as ‘vitamins’ Isoprenoids
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2 Isoprenoids start from the mevalonate pathway Mechanism of prenyltransferase elongation
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3 After double bond epoxidation, squalene serves as backbone for sterol synthesis . = free rotation at these carbons double bond-carbons have fixed positions Bile acids (bile salts) are derivatives of cholesterol.
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Secondary metabolites are extremely important for human senses
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Fiehn BIS103 lecture 12_fall 2010 - Secondary metabolism is...

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