Fiehn BIS103 lecture 14_fall 2010

Fiehn BIS103 lecture 14_fall 2010 - carbon skeletons are...

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1 Nitrogen metabolism breakdown of proteins and amino acids Protein breakdown half-life of some rat liver enzymes
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2 Protein breakdown and transport in the body Breakdown of proteins into amino acids by ubiquitin tags dragging proteins into the 20S proteasome Chemistry Nobel Prize 2004. Irwin Rose, Avram Hershko, Aaron Ciechanover
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3 Breakdown of amino acids: Alanine is converted to pyruvate in the liver to supply substrate for gluconeogenesis
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4 Breakdown of amino acids: Glucogenic amino acids, grouped by site of entry Breakdown of amino acids: Glucogenic amino acids, grouped by site of entry
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5 Breakdown of amino acids:
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Unformatted text preview: carbon skeletons are utilized ammonia is released by oxidative deamination Breakdown of his, arg, pro, glu, gln, orn 6 Breakdown of thr, gly, ala, ser, cys Breakdown of amino acids: ammonia is either directly released (marine organisms) or released as urea (mammals) or uric acids (birds) 7 The urea cycle channels ammonia into urea Net reaction NH 3 + HCO 3-+ aspartate + 3 ATP b urea + AMP + 2 ADP + 2 Pi + PP i + fumarate Urea cycle: Activation of bicarbonate costs 2 ATP 8 The urea and TCA cycle are linked in different organelles...
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This note was uploaded on 01/08/2011 for the course BIS 103 taught by Professor Abel during the Winter '08 term at UC Davis.

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Fiehn BIS103 lecture 14_fall 2010 - carbon skeletons are...

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