Fiehn BIS103 lecture 15_fall 2010

Fiehn BIS103 lecture 15_fall 2010 - b G6P At low glucose...

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1 Metabolism: The Bigger Picture. Regulation and integration Compartments have different functions: reactions are separated.
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2 Energy metabolism integrates important reactions between organs Organs have different functions: not all reactions are shared
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3 Body activity consumes ATP Obviously, the need for energy and energy-related reactions is dependent on the level of activity
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4 Sources of ATP change (and so does race velocity) at prolonged activity The need for food uptake is not as large as some believe….
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5 The body has to cope with rhythms of food 5 mM or 90 mg/100ml blood glucose is normal glucose =C 6 H 12 O 6 1 M = 72+12+96 = 180 g/l = 180 mg/ml 1 mM = 0.18 mg/ml 5 mM = 0.9 mg/ml = 90 mg/100ml Blood glucose
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Unformatted text preview: b G6P At low glucose levels, hexokinase (in all cells) is far more active than glucokinase (liver) At high glucose levels, hexokinase, but not glucokinase, is inhibited by G6P 6 In the fasted state, blood glucose levels decrease (but are still in normal range!), and -oxidation of fatty acids leads to increase in ketone bodies which can be used as energy in muscle and brain At prolonged fasting, sources of ATP change dramatically 7 Supply of glucose in fasted and fed state fasted fed/ stress Preparation for activity and action: The Cori Cycle Gerti Cori Carl Cori Nobel Prize for Medicine 1947 http://www.elmhurst.edu/~chm/vchembook/615coricycle.html...
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This note was uploaded on 01/08/2011 for the course BIS 103 taught by Professor Abel during the Winter '08 term at UC Davis.

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Fiehn BIS103 lecture 15_fall 2010 - b G6P At low glucose...

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