heart1 - Overview of the Pathology of Atherosclerosis and...

Info iconThis preview shows pages 1–11. Sign up to view the full content.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: Overview of the Pathology of Atherosclerosis and Coronary Artery Disease Scott V. Smith, MD Assistant Professor Department of Pathology and Laboratory Medicine Modified by Howard Reisner Ph.D. For Bio 008-2004 Circulatory System: Overview (1) Circulatory System: Overview (2) Atherosclerosis • Definition - A disease of large and medium-sized arteries resulting in progressive accumulation of smooth muscle cells, lipids and connective tissue within intima • Intimal thickening, fibrofatty plaques and narrowing of vessel lumen • Major complications account for >50% annual mortality in United States • Ischemic heart disease is the leading cause of death in United States Large (Elastic) Artery Arterial Distribution • Major Sites of Atherosclerosis – Abdominal aorta – Coronary arteries – Popliteal arteries (behind knee) – Descending thoracic aorta – Internal carotids – Circle of Willis (near brain) • Related to Pressure, Turbulence ? Epidemiology • Global distribution • Epidemic in economically developed societies • Atherosclerosis is a slowly progressive disease beginning in childhood – Raised lesion likely precursor • Symptoms begin in middle age when arterial lesions precipitate organ injury Major Risk Factors • Potentially Modifiable Risk Factors – Hyperlipidemia (esp Hypercholesterolemia) – Hypertension – Cigarette smoking – Diabetes mellitus • Non-modifiable Risk Factors – Advanced age – Male gender – Family history Minor Risk Factors • Obesity – Induces hypertension, diabetes, increased trigylcerides, decreased HDL • Physical inactivity • Stress (“type A” personality) • Increased plasma homocysteine levels – Reactive oxygen species, endothelial dysfunction Pathogenesis (1) • Chronic inflammatory response of arterial wall initiated by endothelial injury • Slowly progressive accumulation of smooth muscle, macrophages, lymphocytes, and connective tissue within intima • Endothelial breakdown and platelet adhesion • Expansion and thrombosis may result in vessel occlusion Early raised lesion & progression Pathogenesis (2) • Chronic inflammatory response of arterial wall initiated by endothelial injury • Slowly progressive accumulation of smooth muscle, macrophages,...
View Full Document

This note was uploaded on 01/09/2011 for the course PATH 128 taught by Professor Reisner during the Fall '10 term at UNC.

Page1 / 41

heart1 - Overview of the Pathology of Atherosclerosis and...

This preview shows document pages 1 - 11. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online