The virus and the immune system

The virus and the immune system - AIDS Course: Virology and...

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University of North Carolina 01/10/11 AIDS Course: Virology and Immunology Charles van der Horst, MD Professor of Medicine
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University of North Carolina 01/10/11
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University of North Carolina 01/10/11
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University of North Carolina 01/10/11 HIV-1 Attachment and Fusion Adapted from: Moore JP, et al. Proc Natl Acad Sci U S A. 2003;100:10598-10602. Virus-Cell Fusion gp41 gp120 V3 loop CD4+ Binding CD4+ Cell membrane Coreceptor Binding CCR5/CXCR4 (R5/X4)
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University of North Carolina 01/10/11
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University of North Carolina 01/10/11
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University of North Carolina 01/10/11
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University of North Carolina 01/10/11
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University of North Carolina 01/10/11
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University of North Carolina 01/10/11
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University of North Carolina 01/10/11
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University of North Carolina 01/10/11
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University of North Carolina 01/10/11 Symptomatic Primary HIV Infection Symptom Schacker Kinloch-Loes Fever 93% 87% Fatigue 90% 26% Pharyngitis 70% 48% Weight loss 70% 13% Myalgias 60% 42% Headache 55% 39%
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University of North Carolina 01/10/11
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University of North Carolina 01/10/11 Man’s Protection from Disease Skin or Mucous Membrane Humoral or Antibody Mediated Immunity (B lymphocytes) Cell Mediated Immunity (Other lymphocytes)
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University of North Carolina 01/10/11
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University of North Carolina 01/10/11 T4, CD4 T8,CD8 Natural Killer Red blood cells
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University of North Carolina 01/10/11 Antigen A molecule which is recognized by antibody and by cells of the immune system
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University of North Carolina 01/10/11
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University of North Carolina 01/10/11
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University of North Carolina 01/10/11 Moller and Chen. 2002. Am.J.Respir.Cell.Mol.Biol. 27:391
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University of North Carolina 01/10/11
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This note was uploaded on 01/09/2011 for the course PUBH 420 taught by Professor Strauss during the Spring '09 term at UNC.

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The virus and the immune system - AIDS Course: Virology and...

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