CHE134 Summer Lecture 5

CHE134 Summer Lecture 5 - O C OH O C O CH3 ASPIRIN ACETYL...

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ASPIRIN ACETYL SALICYLIC ACID A TRUE WONDER DRUG 3 EXERCISES DEAL WITH ASPIRIN SYNTHESIS pH TITRATION COLORIMETRIC DETERMINATION C OH O O C O CH 3 C
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OBJECTIVE: To synthesize aspirin, isolate the product and perform some tests of its purity. CONCEPTS: Synthesis Product Starting Material Theoretical yield Percent yield Temperature dependence of solubility Organic functional groups Condensation Reaction TECHNIQUES: vacuum filtration crystallization melting point quantitative transfer of liquids and solids EQUIPMENT: Buchner Funnel Filter Flask Melting Point Apparatus
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SYNTHESIS Conducting one or more chemical reactions using STARTING MATERIALS to produce the desired substance as a PRODUCT What makes a synthesis EFFECTIVE ? IF IT PRODUCES THE DESIRED PRODUCT: under practical CONDITIONS accessible temperature & pressure from reasonable STARTING MATERIALS at a reasonable RATE CATALYSTS may be helpful with relatively high YIELD
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in a chemical environment that permits practical SEPARATION OF PRODUCT from excess starting materials and byproducts in an ENVIRONMENTALLY RESPONSIBLE way - GREEN CHEMISTRY all, in a CO$T-EFFECTIVE manner For substances that will be consumed by humans or animals, there is an additional concern: SYNTHESIS must produce NO TOXIC BYPRODUCTS that are NOT EASILY REMOVED X
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Chemical reactions rarely result in a SINGLE PRODUCT . There are usually BYPRODUCTS and, often, only ONE reactant will be consumed producing LEFT OVER REACTANTS Many reactions don’t go to “ COMPLETION”. but REACTANTS and PRODUCTS establish The Limiting Reagent EQUILIBRIUM Reactants Products If so, reaction conditions can be chosen to “PUSH” EQUILIBRIUM to favor PRODUCTS (Le Chatelier’s Principle)
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NET RESULT Must be able to separate product from reaction mixture Separation may be based on: Solubility – Extraction / Crystallization Boiling Point – Distillation Chromatography Etc.
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Possible STARTING MATERIALS for the synthesis of ASPIRIN , C9H8O4 ?
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This note was uploaded on 01/09/2011 for the course CHE 134 taught by Professor Staff during the Summer '08 term at SUNY Stony Brook.

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CHE134 Summer Lecture 5 - O C OH O C O CH3 ASPIRIN ACETYL...

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