Introduction to Genetic Analysis 13

Introduction to - 12 Chapter 1 • Genetics and the Organism this type of analysis The basic approach is to find out how the cellular chemistry is

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Unformatted text preview: 12 Chapter 1 • Genetics and the Organism this type of analysis. The basic approach is to find out how the cellular chemistry is disturbed in the mutant individual and, from this information, deduce the role of the gene. The deductions from many genes are assembled to reveal the larger picture. 4. Microscopic analysis. Chromosome structure and movement have long been an integral part of genetics, but new technologies have provided ways of labeling genes and gene products so that their locations can be easily visualized under the microscope. 5. Direct analysis of DNA. Because the genetic material is composed of DNA, the ultimate characterization of a gene is the analysis of the DNA sequence itself. Many techniques, including gene cloning, are used to accomplish this. Cloning is a procedure by which an individual gene can be isolated and amplified (copied multiple times) to produce a pure sample for analysis. One way of doing this is by inserting the gene of interest into a small bacterial chromosome and allowing bacteria to do the job of copying the inserted DNA. After the clone of a gene has been obtained, its nucleotide sequence can be determined, and hence important information about its structure and function can be obtained....
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This note was uploaded on 01/10/2011 for the course BIOL BIOL taught by Professor Johnson during the Spring '08 term at Aberystwyth University.

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