Introduction to Genetic Analysis 54

Introduction to Genetic Analysis 54 - likelihood of the...

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grandmother of his mother Alexandra. Nowadays, he- mophilia can be treated medically, but it was formerly a potentially fatal condition. It is interesting to note that in the Jewish Talmud there are rules about exemp- 53 2.2 Sex chromosomes and sex-linked inheritance Figure 2-26 The inheritance of the X-linked recessive condition hemophilia in the royal families of Europe. A recessive allele causing hemophilia (failure of blood clotting) arose in the reproductive cells of Queen Victoria, or one of her parents, through mutation. This hemophilia allele spread into other royal families by intermarriage. (a) This partial pedigree shows affected males and carrier females (heterozygotes). Most spouses marrying into the families have been omitted from the pedigree for simplicity. Can you deduce the
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Unformatted text preview: likelihood of the present British royal familys harboring the recessive allele? (b) A painting showing Queen Victoria surrounded by her numerous descendants. [Part a, after C. Stern, Principles of Human Genetics , 3d ed. Copyright 1973 by W. H. Freeman and Company; part b, Royal Collection, St. Jamess Palace. Copyright Her Majesty Queen Elizabeth II.] tions to male circumcision that show clearly that the mode of transmission of the disease through unaffected carrier females was well understood in ancient times. For example, one exemption was for the sons of (a) (b) 44200_02_p27-72 3/2/04 11:38 AM Page 53...
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