Introduction to Genetic Analysis 73

Introduction to - 44200_02_p27-72 11:38 AM Chapter 2 • Patterns of Inheritance pecting a child They find out that they are distantly related

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Unformatted text preview: 44200_02_p27-72 3/2/04 11:38 AM Page 72 72 Chapter 2 • Patterns of Inheritance pecting a child. They find out that they are distantly related. Part of the family tree is shown here. a. State concisely exactly what is unusual about this pedigree. b. Can the pattern be explained by (i) Chance (if so, what is the probability)? (ii) Cytoplasmic factors? (iii) Mendelian inheritance? Explain. 57. Consider the accompanying pedigree for a rare human muscle disease. ? How would you advise the parents about the probability of their child’s being a deaf boy, a deaf girl, a normal boy, or a normal girl? Be sure to state any assumptions that you make. 56. The accompanying pedigree shows a very unusual inheritance pattern that actually did exist. All progeny are shown, but the fathers in each mating have been omitted to draw attention to the remarkable pattern. a. What is the unusual feature that distinguishes this pedigree from those studied earlier in this chapter? b. Where in the cell do you think the mutant DNA resides that is responsible for this phenotype? INTERACTIVE GENETICS MegaManual CD-ROM Tutorial Mendelian Analysis For additional practice with Mendelian inheritance problems, refer to the Interactive Genetics CD-ROM included with the Solutions MegaManual. The Mendelian Analysis activity includes 12 interactive problems, which focus on using inheritance, pedigrees, and probability data to solve problems. EXPLORING GENOMES A Web-Based Bioinformatics Tutorial OMIM and Huntington Disease The Online Mendelian Inheritance in Man (OMIM) program collects data on the genetics of human genes. In the Genomics tutorial at www.whfreeman.com/iga, you will learn how to search OMIM for data on gene locus and inheritance pattern for conditions such as Huntington disease. ...
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This note was uploaded on 01/10/2011 for the course BIOL BIOL taught by Professor Johnson during the Spring '08 term at Aberystwyth University.

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