Introduction to Genetic Analysis 118

Introduction to Genetic Analysis 118 - 44200_04_p115-150...

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117 4.1 The discovery of the inheritance patterns of linked genes the same chromosome? Do such allele pairs show any regularities in their patterns of inheritance? Are there diagnostic ratios or other patterns that are associated with such genes? The answer to these questions is “Yes, there are simple patterns that are unique to genes that reside on the same chromosome.” These patterns are the topic of the present chapter. Once again, a key element of the analysis is the di- hybrid—an individual that is heterozygous for two genes of interest (say, A / a and B / b ). Suppose that the two genes are on the same chromosome. Such dihybrids could be represented as follows: At the simplest level, this chapter analyzes the inheri- tance patterns produced in the descendants of such dihybrids. What would be the result of crossing the above dihy- brid? Rather than sorting independently, A and B will most likely be inherited together, as will a and b (they are after all attached by the chromosome segment between them). As a consequence, the inheritance pattern that re- sults will be different from those resulting from indepen- dent assortment. In some cases, however, the combina-
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