Introduction to Genetic Analysis 150

Introduction to Genetic Analysis 150 - 44200_04_p115-150...

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3 4 5 39. The human genes for colorblindness and for hemo- philia are both on the X chromosome, and they show a recombinant frequency of about 10 percent. Linkage of a pathological gene to a relatively harm- less one can be used for genetic prognosis. Shown be- low is part of a more extensive pedigree. Blackened symbols indicate that the subjects had hemophilia, and crosses indicate colorblindness. What informa- tion could be given to women III-4 and III-5 about the likelihood of their having sons with hemophilia? (Problem 39 adapted from J. F. Crow, Genetics Notes: An Introduction to Genetics . Burgess, 1983.) 40. A geneticist mapping the genes A , B , C , D , and E makes two 3-point testcrosses. The ±rst cross of pure lines is A / A ? B / B ? C / C ? D / D ? E / E 3 a / a ? b / b ? C / C ? d / d ? E / E The geneticist crosses the F 1 with a recessive tester and classi±es the progeny by the gametic contribu- tion of the F 1 : A ? B ? C ? D ? E 316 a ? b ? C ? d ? E 314 A ? B ? C ? d ? E 31 a ? b ? C ? D ? E 39 A ? b ? C ? d ? E 130 a ? B ? C ? D ? E 140 A ? b ? C ? D ? E 17 a ? B ? C ? d ? E 13 1000 12345 I II III
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