Introduction to Genetic Analysis 174

Introduction to Genetic Analysis 174 - 173 5.5 Transduction...

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Unformatted text preview: 173 5.5 Transduction produces a cytoplasmic factor that represses the multi- plication of the virus. (The phage-directed cytoplasmic repressor nicely explains the immunity of the lysogenic bacteria, because a phage would immediately encounter a repressor and be inactivated.) l INSERTION The interrupted-mating experiments described above showed that the l prophage is part of the lysogenic bacteriums chromosome. How is the l prophage inserted into the bacterial genome? In 1962, Allan Campbell proposed that it inserts by a single crossover between a circular l chromosome and the cir- cular E. coli chromosome, as shown in Figure 5-30. The crossover point would be between a specific site in l , the l attachment site, and an attachment site in the bac- terial chromosome located between the genes gal and bio, because l integrates at that position in the E. coli chromosome. The crossing-over is mediated by a phage- encoded recombination system....
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