Introduction to Genetic Analysis 600

Introduction to Genetic Analysis 600 - The key to...

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Unformatted text preview: The key to allocating the different roles to these cells is another single cell, called the anchor cell, which lies underneath the cells of the equivalence group (Figure 18-29c). The anchor cell secretes a polypeptide ligand that binds to a receptor tyrosine kinase (RTK) present on all the cells of the equivalence group. Only the cell that receives the highest level of this signal (the equivalence-group cell nearest the anchor cell) becomes a primary vulva cell. Only its signal-transduction path- way is sufficiently triggered so that it in turn can activate the transcription factors necessary to become a primary cell (Figure 18-29d). Thus we can say that the anchor cell operates through an inductive interaction to commit a cell to the primary vulva fate. Having acquired its fate, the primary vulva cell sends out a different signal to its immediate neighbors in the equivalence group. That signal inhibits those cells from similarly interpreting the anchor-cell signal, thus preventing them from also adopting the primary role.preventing them from also adopting the primary role....
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This note was uploaded on 01/10/2011 for the course BIOL BIOL taught by Professor Johnson during the Spring '08 term at Aberystwyth University.

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