Introduction to Genetic Analysis 628

Introduction to Genetic Analysis 628 - 44200_19_p611-642...

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only 1.0 3 1/100,000 5 0.00001, and the frequency of A alleles would be 0.99999. After yet another genera- tion of mutation, the frequency of a would be increased by 0.99999 3 1/100,000 5 0.000009 to a new fre- quency of 0.000019, whereas the original allele would be reduced in frequency to 0.999981. It is obvious that the rate of increase of the new allele is extremely slow and that it gets slower every generation because there are fewer copies of the old allele still left to mutate. A gen- eral formula for the change in allele frequency under mutation is given in Box 19-3. 19.3 Sources of variation 627 Point-Mutation Rates in Different Organisms Organism Gene Mutation rate per generation Bacteriophage Host range 2.5 3 10 2 9 Escherichia coli Phage resistance 2 3 10 2 8 Zea mays (corn) R (color factor) 2.9 3 10 2 4 Y (yellow seeds) 2 3 10 2 6 Drosophila melanogaster Average lethal 2.6 3 10 2 5 Source: T. Dobzhansky, Genetics and the Origin of Species, 3d ed., rev. Columbia University Press, 1951.
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This note was uploaded on 01/10/2011 for the course BIOL BIOL taught by Professor Johnson during the Spring '08 term at Aberystwyth University.

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