Introduction to Genetic Analysis 507

Introduction to Genetic Analysis 507 - 506 Chapter 15...

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Unformatted text preview: 506 Chapter 15 Large-Scale Chromosomal Changes heterozygote. In meiotic prophase, tandem duplication heterozygotes show a loop comprised of the unpaired extra region. Synthetic duplications of known coverage can be used for gene mapping. In haploids, for example, a chro- mosomally normal strain carrying a new recessive muta- tion m may be crossed to strains bearing a number of duplication-generating rearrangements (for example, translocations and pericentric inversions). In any one cross, if some duplication progeny are m in phenotype, the duplication does not span gene m, because if it did, its extra segment would mask the recessive m allele. Identifying chromosome mutations by genomics DNA microarrays (see Figure 12-27) have made it possi- ble to detect and quantify duplications or deletions of a given DNA segment. The technique is called compara- tive genomic hybridization. The total DNA of the wild type and of a mutant are labeled with two different fluo- rescent dyes that emit distinct wavelengths of light....
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This note was uploaded on 01/10/2011 for the course BIOL BIOL taught by Professor Johnson during the Spring '08 term at Aberystwyth University.

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