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Unformatted text preview: 522 Chapter 16 • Dissection of Gene Function CHAPTER OVERVIEW A common endeavor of genetic analysts is to under- stand the functions of the genes that affect some particular biological process of interest. The traditional approach of genetics is to do this by first looking at abnor- mal gene function. The strategy is to disrupt normal gene activity and then analyze the phenotypes of the resulting mutant organisms, which provide clues to the function of the disrupted gene. As we will see, the genetic approach to disrupting gene activity is through mutation. In recent years, alternative techniques have emerged (generally called phenocopying) that disrupt gene expression or ac- tivity. Unlike mutations these disruptions are not inher- ited. This chapter will explore both these approaches. The major focus, however, will be on mutational approaches, since they allow for a wider and deeper exploration of a gene’s normal biological contributions....
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This note was uploaded on 01/10/2011 for the course BIOL BIOL taught by Professor Johnson during the Spring '08 term at Aberystwyth University.
- Spring '08