Introduction to Genetic Analysis 534

Introduction to Genetic Analysis 534 - Reverse genetics by...

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Unformatted text preview: Reverse genetics by phenocopying The advantage of inactivating a gene itself is that muta- tions will be passed on from one generation to the next, so that once obtained a line of mutants is always avail- able for future study. However, only organisms well de- veloped as molecular genetic models can be used for such manipulations. On the other hand, phenocopying can be applied to a great many organisms regardless of how well developed the genetic technology is for a given species. The next two sections describe two phenocopy- ing techniques. RNA INTERFERENCE An exciting finding of the past ten years has been the discovery of another widespread mechanism whose natural function seems to be to pro- tect the cell from foreign DNA. This mechanism is called RNA interference, or RNAi. As with RIP, re- searchers have capitalized on this cellular mechanism to make a powerful method for inactivating specific genes....
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This note was uploaded on 01/10/2011 for the course BIOL BIOL taught by Professor Johnson during the Spring '08 term at Aberystwyth University.

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