Introduction to Genetic Analysis 544

Introduction to Genetic Analysis 544 - 44200_16p521-544...

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34. Every mutagen produces a certain characteristic type of mutational event. Explain your answers to the following questions: a. Would you expect hypomorphic mutations to be more frequent among all mutations produced by base-substitution mutagens or by frameshift mutagens? b. Would you expect null mutations to be more frequent among all mutations produced by base- substitution mutagens or by frameshift mutagens? 35. Neomorphic mutations can be reverted by treat- ment with standard mutagens. When the revertants are examined, they typically turn out to be recessive loss-of-function mutations. Explain this observation. 36. You are trying to identify all mutations that affect development of the dorsal Fn in the zebra Fsh. You do an ± 3 mutagenesis analysis for recessive muta- tions that cause loss of the dorsal Fn. By recombina- tion and complementation analysis, you Fnd that 40 mutations you’ve isolated represent mutations in Fve genes, with 12 mutations in one gene, 10 muta- tions in each of two others, 7 mutations in a fourth gene, and only 1 mutation in a Ffth.
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