Introduction to Genetic Analysis 546

Introduction to Genetic Analysis 546 - of the cell cycle...

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545 GENETIC REGULATION OF CELL NUMBER: NORMAL AND CANCER CELLS (a) (b) KEY QUESTIONS Why is it important for multicellular organisms to have mechanisms for regulating cell numbers? Why is cell-cycle progression regulated? Why is programmed cell death necessary? How do neighboring cells influence cell proliferation and cell death? Why is cancer considered a genetic disease of somatic cells? How do mutations promote tumors? How can genomic methodologies be applied to cancer research and medicine? OUTLINE 17.1 The balance between cell loss and cell proliferation 17.2 The cell-proliferation machinery
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Unformatted text preview: of the cell cycle 17.3 The machinery of programmed cell death 17.4 Extracellular signals 17.5 Cancer: the genetics of aberrant cell number regulation 17.6 Applying genomic approaches to cancer research, diagnosis, and therapies Cell death in Drosophila embryo. (a) Wild-type embryo in which the bright spots are cells carrying out a genetic program to die (apoptosis). (b) Mutant embryo in which this genetic program does not proceed. [Kristin White, Massachusetts General Hospital and Harvard Medical School.] 17 44200_17_p545-574 3/23/04 11:52 Page 545...
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