Introduction to Genetic Analysis 552

Introduction to Genetic Analysis 552 - 551 17.2 The...

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Unformatted text preview: 551 17.2 The cell-proliferation machinery of the cell cycle MODEL ORGANISM Yeast Yeast As a Model for the Cell Cycle Work initiated by Leland Hartwell and his associates on the cell-cycle genetics of the budding yeast Saccha- romyces cerevisiae revealed a large array of genetic functions that maintain the proper cell cycle. These functions were identified as a specific subset of temperature-sensitive (ts) mutations called cdc (cell division cycle) mutations. When grown at low tempera- ture, yeasts with these cdc mutations grew normally. When shifted to higher, restrictive temperatures, the yeasts stopped growing. What made these cdc mutations novel among the more general class of ts mu- tations was that a particular cdc mutant would stop growing at a specific time in the cell cycle, and all the yeast cells would look alike. Consider some examples of S. cerevisiae, a yeast that divides through budding, a process in which a mother cell develops a small out- pocketing, a bud. The bud grows and mitosis takespocketing, a bud....
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