Introduction to Genetic Analysis 570

Introduction to Genetic Analysis 570 - bly through the...

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Unformatted text preview: bly through the overexpression of telomerase.) Even malignant tumors differ in their rates of proliferation and their ability to invade other tissues, or metastasize. Undoubtedly, even after a malignant state is achieved, many more mutations accumulate in the tumor cell that further promote its proliferation and invasiveness. Thus, there is a considerable way to go before we have a truly comprehensive view of how tumors arise and progress. Even so, there is light at the end of the tunnel. In the early 1990s, researchers were able to correlate overex- pression of the Abelson tyrosine kinase, through the Philadelphia chromosome gene fusion, with chronic myelogenous leukemia. Chemists then developed a com- pound, called ST1571, that bound to the ATP- binding site of the Abelson tyrosine kinase and thereby inhibited its ability to phosphorylate tyrosines on target proteins. ST1571 was shown to inhibit cell proliferation induced by bcr abl in cell lines and was then tested as the drug Gleevec in clinical trials. The treatment had dra-the drug Gleevec in clinical trials....
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This note was uploaded on 01/10/2011 for the course BIOL BIOL taught by Professor Johnson during the Spring '08 term at Aberystwyth University.

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