Introduction to Genetic Analysis 574

Introduction to Genetic Analysis 574 - Exploring the Cancer...

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22. The wild-type Rb protein functions to sequester E2F in the cytoplasm. At the appropriate time in the cell cycle, E2F is released so that it can act as a functional transcription factor. a. In cells homozygous for a loss-of-function rb mu- tation, where in the cell do you expect to ±nd E2F? b. If a cell were doubly homozygous for loss-of- function mutations in both the RB and E2F genes, would you expect tumor growth? Explain. c. How would a mutation in the RB protein that irreversibly binds E2F affect the cell cycle? EXPLORING GENOMES A Web-Based Bioinformatics Tutorial
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Unformatted text preview: Exploring the Cancer Anatomy Project The Cancer Anatomy project at NCBI is a specialized database focused on a particular subset of data. It brings together, in a graphical and searchable format, all known information about individual genes, map positions, and chromosomal location for genes associated with cancer. In the Genomics tutorial at, we explore gene-expression data, gene mutations, and chromosomal aberrations associated with the various tumor types. 573 Problems 44200_17_p545-574 3/17/04 10:17 AM Page 573...
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