Introduction to Genetic Analysis 584

Introduction to Genetic Analysis 584 - 44200_18_p575-610...

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583 18.4 Forming complex pattern: establishing positional information Create a system that can mount a differential response to that local concentration, thereby creating multiple cell states (part d). Create mechanisms for cross talk between the cells of different states, such that cells can take on additional cell states, reFne their positions, and adjust their numbers (part e). As key decisions are made, develop systems that allow these decisions to become Fxed in the molecular memory banks of a cell and its descendants. We will focus largely on the construction of the basic Drosophila body plan in the embryo as a well- understood application of the logic of this choreography. SpeciFcally, we will look at the establishment of the two major body axes of the embryo: anterior–posterior (head to tail) and dorsal–ventral (back to front). Devel- opment of these two axes leads to the following events: Subdivision of the embryonic anterior–posterior axis into a series of distinct units called segments, or metameres, and assignment of distinct roles to each
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This note was uploaded on 01/10/2011 for the course BIOL BIOL taught by Professor Johnson during the Spring '08 term at Aberystwyth University.

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