Introduction to Genetic Analysis 401

Introduction to Genetic Analysis 401 - 44200 GRIFFITHS...

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44200 12 Chapter 12 Genomics 44200 GRIFFITHS FREEM Ch-12 First Pages Sen 12-10-2003 p 12 Application File SIMPLE-SEQUENCE LENGTH POLYMORPHISMS We learned in Chapter 4 that one category of repetitive DNA has repeats of a very simple short sequence. DNA markers based on variable numbers of short-sequence repeats are collectively called simple-sequence length polymorphisms (SSLPs). SSLPs have two basic advantages over RFLPs. First, an RFLP usually has only 1 or 2 “alleles,” or morphs, in a pedigree or population under study. In contrast, SSLPs commonly have multiple alleles, and as many as 15 alle- les have been found for an SSLP locus. As a consequence, sometimes 4 alleles (2 from each parent) can be tracked in a pedigree. Two types of SSLPs are now routinely used in genomics—minisatellite and microsatellite markers. Minisatellite markers Minisatellite markers are based on variation of the number of VNTRs (variable number tandem repeats). The VNTR loci in humans are from 1-
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