Introduction to Genetic Analysis 405

Introduction to Genetic Analysis 405 - 44200 GRIFFITHS...

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44200 16 Chapter 12 Genomics 44200 GRIFFITHS FREEM Ch-12 First Pages Sen 12-10-2003 p 16 Application File Linkage map Sequence map Probe for marker B Probe for marker C Probe for marker A Probe for marker D Probe for marker E Cytogenetic map Clones of physical map Physical map A AGTC T Base change of marker A Base change of marker C TGA TCCTGA G C DB E C Figure 12-17 Uniting linkage and cytogenetic maps with molecular maps. To connect the different map types, molecular markers from linkage and cytogenetic maps are anchored onto the physical map and the genomic sequence map. Why are we interested in such structural rearrange- ments in the context of maps? The reason is that some breaks cause mutant phenotypes, either because a gene that happens to reside at the breakpoint is deactivated or because the junction fuses two genes together, creating a novel gene. Some deletions also cause mutant pheno- types. Hence a link can be made between a mutation and a chromosomal position. How can we map rearrangement breakpoints relative to molecular markers? One approach
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This note was uploaded on 01/10/2011 for the course BIOL BIOL taught by Professor Johnson during the Spring '08 term at Aberystwyth University.

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