Introduction to Genetic Analysis 406

Introduction to Genetic Analysis 406 - on File 44200...

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12.4 Using Genomic Sequence to Find a Specific Gene 17 44200 GRIFFITHS FREEM Ch-12 First Pages Sen 12-10-2003 p 17 Application File on File detect molecular markers can be applied to the set of genomic clones that have been arranged into a physical map. This will reveal the locations of the molecular markers on the physical map (Figure 12-17, top). ATTACHING THE MOLECULAR MARKERS TO GE- NOMIC SEQUENCE MAPS Typically, probes for map- ping molecular markers have already been sequenced. Even if they haven’t been, sequencing them is easily ac- complished. Once the sequence is known, we can search the sequence map with a computer to identify the lo- cation of the identical sequence in the genome (Figure 12-17, bottom). Thus, the locations of the molecular markers can be identified on the sequence map down to single-base-pair resolution. RELATING MUTATIONS AND REARRANGEMENT BREAKPOINTS TO THE SEQUENCE MAP Everything discussed thus far in this section is prelude. Our real goal is to find a gene of interest. Therefore the task is
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