Introduction to Genetic Analysis 410

Introduction to Genetic Analysis 410 - accurate. Chromosome...

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12.5 Bioinformatics: Meaning from Genomic Sequence 21 44200 GRIFFITHS FREEM Ch-12 First Pages Sen 12-10-2003 p 21 Application File on File Polyadenylation site Translation start site Translation termination site Splice sites Splice sites Intron Intron Intron Exon Exon Predicted gene Exon Promoter site Predictions from docking- site analysis programs Predictions from mRNA and its properties Predictions from protein BLAST similarity Codon bias Sequence motif EST cDNA 5´ UTR 3´ UTR Open reading frame (ORF) Figure 12-22 Making gene predictions. The different forms of gene-product evidence—cDNAs, ESTs, BLAST similarity hits, codon bias, and motif hits—are integrated to make gene predictions. Where multiple classes of evidence are found to be associated with a particular genomic DNA sequence, there is greater confidence in the likelihood that a gene prediction is
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Unformatted text preview: accurate. Chromosome 20 Figure 12-23 The sequence map of human chromosome 20. The recombinational and cytogenetic map coordinates are shown in the top lines of the figure. Various graphics depicting gene density and different DNA properties are shown in the middle sections. The identifiers of the predicted genes are shown at the bottom of the panel. [Courtesy of Jim Kent, Ewan Birney, Darryl Leja, and Francis Collins. Adapted from the International Human Genome Sequencing Consortium, Initial Sequencing and Analysis of the Human Genome, Nature 409, 2001, 860921.]...
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This note was uploaded on 01/10/2011 for the course BIOL BIOL taught by Professor Johnson during the Spring '08 term at Aberystwyth University.

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