Introduction to Genetic Analysis 411

Introduction to Genetic Analysis 411 - 44200 GRIFFITHS...

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44200 22 Chapter 12 Genomics 44200 GRIFFITHS FREEM Ch-12 First Pages Sen 12-10-2003 p 22 Application File predictions are being revised continually as new data and new computer programs become available. The cur- rent state of the predictions can be viewed at many Web sites, most notably at the public DNA data banks in the United States and Europe (see Appendix B). These pre- dictions are current best guesses of the protein-coding genes present in the sequenced species and, as such, are works in progress. rent cDNA and EST data, 60 percent of human protein- coding genes are likely to have two or more splice vari- ants. On average, there are about three splice variants per gene. Hence the number of distinct proteins en- coded by the human genome is about threefold greater than the number of recognized genes. Proteins can be grouped into families of structurally and functionally related proteins on the basis of similar- ity in amino acid sequence. For a given protein family that is known in many organisms, the number of pro- teins in a family is larger in humans than in other inver- tebrates whose genomes have been sequenced. Proteins are composed of modular domains, with modules mixed and matched to carry out different roles. Many domains are associated with specific biological functions. The number of modular domains per protein also seems to
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This note was uploaded on 01/10/2011 for the course BIOL BIOL taught by Professor Johnson during the Spring '08 term at Aberystwyth University.

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