Introduction to Genetic Analysis 412

Introduction to Genetic Analysis 412 - on File 44200...

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12.6 Take-Home Lessons from the Genomes 23 44200 GRIFFITHS FREEM Ch-12 First Pages Sen 12-10-2003 p 23 Application File on File chromosome 7. About 800 physical map clones have been FISH mapped to human chromosome 7, creating a high-density cytogenetic map (Figure 12-24a). With the use of these clones, about 1600 rearrangement break- points associated with human disease have been FISH mapped (by the method described earlier) and 440 of these breakpoints have been characterized at the sequence level, allowing the association of mutant phenotype and genes found in the DNA sequences (Figure 12-24b). Deciphering encoded information through comparative genomics The area of genomics that compares and contrasts genomes from different organisms is called comparative genomics. It provides a powerful method of identifying essential sequences. Retention of an identical sequence in many different groups in the years since their diver- gence is taken as evidence that the sequence is being
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This note was uploaded on 01/10/2011 for the course BIOL BIOL taught by Professor Johnson during the Spring '08 term at Aberystwyth University.

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