Introduction to Genetic Analysis 415

Introduction to Genetic Analysis 415 - 44200 26 Chapter 12...

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Unformatted text preview: 44200 26 Chapter 12 Genomics 44200 GRIFFITHS FREEM Ch-12 First Pages Sen 12-10-2003 p 26 Application File bait. On another plasmid, a gene for another protein under investigation is spliced to the activation domain and the resulting fusion protein is said to be the tar- get (Figure 12-29). The two hybrid plasmids are then introduced into the same yeast cellperhaps by mat- Figure 12-28 Display of gene-expression patterns detected by DNA microarrays. Each row is a different gene and each column a different time point. Red means that transcript levels for the gene are higher than at the initial time point; green means that transcript levels are lower. The four columns labeled +cyc are from cells grown on cycloheximide, meaning that no protein synthesis was taking place in these cells. [Mike Eisen and Vishy Iyer, Stanford University. Image appeared in Nature Genetics , vol. 18, March 1998, p. 196, Figure 1.] DNA microarrays: Using an oligonucleotide array to analyze patterns of gene expression...
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