Introduction to Genetic Analysis 418

Introduction to Genetic Analysis 418 - on File 44200...

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Problems 29 44200 GRIFFITHS FREEM Ch-12 First Pages Sen 12-10-2003 p 29 Application File on File c. How many map units separate the three RFLP loci? Solution This is a mapping problem, but with the twist that some of the markers are traditional types (which we have en- countered in preceding chapters) and others are molecu- lar markers (in this case, RFLPs). Nevertheless, the prin- ciple of mapping is the same as that which we used before; in other words, it is based on recombinant fre- quency. In any recombination analysis, we must be clear about the genotype of the parents before we can classify progeny into recombinant classes. In this case, we know that the Oak Ridge parent must contain all O alleles, and Mauriceville all M alleles; therefore, the parents are al 1 O 2 O 3 O 3 al 1 1 M 2 M 3 M and knowing this makes determining recombinant classes easy. We see from the data that the parental classes are the two most common (34 and 36). We first of all notice that the al alleles are tightly linked to RFLP
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