Introduction to Genetic Analysis 420

Introduction to Genetic Analysis 420 - on File 44200...

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Problems 31 44200 GRIFFITHS FREEM Ch-12 First Pages Sen 12-10-2003 p 31 Application File on File became geographically isolated from each other. You detect polymorphisms in this strain by allowing a single sequence to act as primer for PCR. This by chance spans and amplifies various regions of the genome, showing up as bands on a gel. (This is called RAPD analysis, standing for randomly amplified polymorphic DNA.) One primer amplified two bands in haploid strain 1 and no bands in strain 2. These strains were crossed, and seven progeny were analyzed. The results were as follows: a. Draw diagrams that explain the difference be- tween the parents. b. Explain the origin of the progeny and their rela- tive frequencies. c. Draw an example of a single tetrad from this cross, showing the amplified bands. 24. A certain disease is inherited as an autosomal dom- inant N. It was noted that some patients carry chromosomal rearrangements that have in common the property of always having a chromosomal breakpoint in band 3q3.1 on chromosome 3. Four
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