Introduction to Genetic Analysis 480

Introduction to Genetic Analysis 480 - 44200_14_p451-480...

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15. In the double-strand break model, list all the stages at which exo- and endonucleases act. 16. Differentiate between the elements of the following pairs: a. Transitions and transversions b. Synonymous and neutral mutations c. Missense and nonsense mutations d. Frameshift and nonsense mutations 17. Why are frameshift mutations more likely than mis- sense mutations to result in proteins that lack nor- mal function? 18. Diagram two different mechanisms for deletion for- mation. What type of information provided from DNA sequencing can distinguish between these possibilities? 19. Describe two spontaneous lesions that can lead to mutations. 20. Compare the mechanism of action of 5-bromouracil (5-BU) with ethylmethanesulfonate (EMS) in caus- ing mutations. Explain the speci±city of mutagenesis for each agent in light of the proposed mechanism. 21. Compare the two different systems required for the repair of AP sites and the removal of photodimers.
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