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Unformatted text preview: chromosome mutations A reciprocal translocation demonstrated by chromosome painting. A suspension of chromosomes from many cells is passed through an electronic device that sorts them by size. DNA is extracted from individual chromosomes, denatured, joined with one of several ﬂuorescent dyes, and then added to partially denatured chromosomes on a slide. The ﬂuorescent DNA “ﬁnds” its own chromosome and binds along its length by base complementarity, thus “painting” it. In this preparation, a bright blue and a pink dye have been used to paint different chromosomes. The preparation shows one normal pink chromosome, one normal light blue, and two that have exchanged their tips. [Lawrence Berkeley Laboratory.] 44200_15_p481-520 3/12/04 1:06 PM Page 481...
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This note was uploaded on 01/10/2011 for the course BIOL BIOL taught by Professor Johnson during the Spring '08 term at Aberystwyth University.
- Spring '08