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Unformatted text preview: 483 15.1 Changes in chromosome number have been best characterized in eukaryotes, and all the ex- amples in this chapter are from that group. Chromosome mutations are important from several biological perspectives. First, they can be sources of insight into how genes act in concert on a genomic scale. Second, they reveal several important features of meiosis and chro- mosome architecture. Third, they constitute useful tools for experimental genomic manipulation. Fourth, they are sources of insight into evolutionary processes. Many chromosome mutations cause abnormalities in cell and organismal function. Most of these abnormal- ities stem from changes in gene number or gene position. In some cases, a chromosome mutation results from chromosome breakage. If the break occurs within a gene, the result is functional disruption of that gene. For our purposes, we shall divide chromosome muta- tions into two groups: changes in chromosome number and changes in chromosome structure. These two groups...
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This note was uploaded on 01/10/2011 for the course BIOL BIOL taught by Professor Johnson during the Spring '08 term at Aberystwyth University.
- Spring '08