EE4047_Part2 - Part 2 Basic Genetic Algorithm City...

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City University of Hong Kong Part 2: Basic Genetic Algorithm Genetic Algorithm ± Natural selection: Survival of the fittest T DNA Nucleotides Codons Genes A C G C C G A T A G A A C G C A T A A A A A A A A T C A A C ... ... ± DNA structures
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Biological DNA Double Helix From Access excellence @ National Health Museum Biological Genetic Background ± Basic elements of deoxyribonucleic acid (DNA) ¾ Purines Adenine ( A ) Guanine ( G ) ¾ Pyrimidines Cytosine ( C ) Thymine ( T ) (in ribonuclei acid RNA, as uracil “ U ”) ¾ C and G are paired together ¾ A and T ( U ) are paired together
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Flow of Genetic Information CGU GGA UCA ACU UUU GCC GUU UCU RNA Protein Translation Transcription DNA Template strand mRNA protein DNA Replication C G C G C G C G C G A T T A A T T A A T A T A T A T C T G A C G C G C G C G A T A T A T C G A T Arg Gly Tyr Thr Phe Ala Val Ser http://www.allaboutscience.org/dna-double-helix-video.htm Recombination ¾ Involving the displacement of a strand in a host DNA duplex by a similar strand from a donor duplex. ¾ Pairing of the displaced host strand with donor strand forms a HOLLIDAY structure of two duplexes lined by crossed single strands. ¾ Can be illustrated by Holliday Model
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Holliday Model for Recombination DNA with strand break is aligned with a 2 nd homologous DNA Reciprocal strand switch produces a Holliday intermediate Holliday Model for Recombination Crossover point moves by branch migration and strand breaks are repaired
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Holliday Model for Recombination Holliday intermediate can be cleaved (resolved) in TWO ways, producing two possible sets of products Non-recombinant Recombinant Mutation ± Normal DNA ± Transition GAC AAG GTG ACG CTG TTC CAC TGC GAC AAG GUG ACG Asp Arg Val Thr GAC G AG GTG ACG CTG C TC CAC TGC GAC GAG GUG ACG Asp Glu Val Thr mRNA DNA Protein
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EE4047_Part2 - Part 2 Basic Genetic Algorithm City...

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