genomeguide

genomeguide - Study guide for the first midterm exam...

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Study guide for the first midterm exam, BME/BIO 80H, The Human Genome From lecture 1 Pre-Mendel ideas on gene transmission: Hippocrates, Aristotle, Preformation, Lamarck, Weismann Hippocrates 400BC – parts of body produced “humors” that are collected for material of heredity. Female + male humors blended to offspring. Aristotle said body parts aren’t inherited, people may look more like distant relatives, traits reappear and disappear in some generations Preformation states that preformed people = homunculus, person inside sperm (spermastic) or egg (ovistic) Lamarck and "Doctrine of Inheritance of Acquired Characteristics" – traits are modified before passing onto offspring, material = gemmules; Darwin said gemmules can be dormant Wismann = bred mice, acquired traits aren’t inherited, put to rest Lamarck’s doctrine Significance of Mendel’s findings Principles of heredity, pea plants, trait passed through inheritance of genes “Laws of Inheritance” Mendel’s successors (from handout; be able to match the name to the contribution/finding) Molecular Genetics (from handout: be able to match the name to the contribution/finding) Uses of Recombinant DNA Technology In biomedicine and agriculture (gene product production/making proteins from cloned genes, DNA/identity in forensics first used in criminology in 1985 Dr. Alec Jeffreys, correction of genetic defects aka GT, genetic screening/diagnostic and predictive tests, production of GMO genetically modified organisms such as Flavr Savr tomato, human genome project Genetic Testing/Screening (developmental stages at which testing can be performed) preimplantation testing of IVF (in-vitro fertilization) embryos, PGD = preimplantation genetic diagnosis. Get cell from embryo, newborn screening (eg. Phenylketonuria, PKU), carrier screening. Individual carries the trait, but doesn’t have the
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This note was uploaded on 01/11/2011 for the course BME 80H taught by Professor Rothwell during the Winter '07 term at UCSC.

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genomeguide - Study guide for the first midterm exam...

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