Biomaterials in Manufacturing-11

Biomaterials in Manufacturing-11 - Biomaterials and...

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Biomaterials and Biomedical Device Manufacturing MET 144 “Materials and Processes 2”
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A biomaterial is "any substance (other than drugs) or combination of substances synthetic or natural in origin, which can be used for any period of time, as a whole or as a part of a system which treats, augments, or replaces any tissue, organ, or function of the body". Biocompatibility The ability of a material to perform with an appropriate host response in a specific application Host Response — The response of the host organism (local and systemic) to the implanted material or device.
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Biomedical Device Manufacturing Just to the northwest of us in Indiana, Zimmer and other biomedical device manufacturers are major employers: Warsaw
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Key Terms/Concepts Metallic/glass/Polymeric/Ceramic/Composite Fracture/fatigue/creep/corrosion/degradation Tissue response/healing/biocompatibility/host response/carcinogenicity Hard/soft tissue implants Vascular/Breast/Urological/Art. Organ Mucosal contacting …
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Material Selection Parameters Mechanical Thermal/Electrical Conductivity Diffusion Water Absorption Bio-stability Biocompatibility
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Bulk Material Surface Layer of Material Adsorbed layer of proteins Cells in biological fluid Biocompatibility is primarily a surface phenomenon
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Test Animals Rabbits – ear, skin, pyrogen Guinea Pigs – skin Mice – genotoxicity Horseshoe Crab – endotoxins Pig – implant Bacteria - genotoxicity People – long term
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Some Commonly Used Biomaterials Material Applications Silicone rubber Catheters, tubing Dacron Vascular grafts Cellulose Dialysis membranes Poly(methyl methacrylate) Intraocular lenses, bone cement Polyurethanes Catheters, pacemaker leads Hydogels Opthalmological devices, drug delivery Stainless steel Orthopedic devices, stents Titanium Orthopedic and dental devices Alumina Orthopedic and dental devices Hydroxyapatite Orthopedic and dental devices Collagen (reprocessed) Opthalmologic applications, wound dressings
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. Bioengineers
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This note was uploaded on 01/13/2011 for the course MET 144 taught by Professor Handy,r during the Spring '08 term at Purdue.

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Biomaterials in Manufacturing-11 - Biomaterials and...

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