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EBME 306 LECTURES 3-5 FALL-2008-ZIATS compressed

EBME 306 LECTURES 3-5 FALL-2008-ZIATS compressed -...

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BIOLOGICAL CONSTRAINTS in USING BIOMATERIALS- INFLAMMATION Readings for November 5, 7 and 10: Biomaterials: The Intersection of Biology and Materials Science , J.S. Temenoff and A.G. Mikos, Pearson/Prentice Hall, 2008, pp.369-384, 327-335, 385-393
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BIOMATERIAL IMPLANT RESPONSE SURGICAL IMPLANT of BIOMATERIAL SURGICAL PROCEDURE INFLAMMATION , IMMUNE RESPONSE, HEALING, TOXICITY, CARINOGENICITY TISSUE RETRIEVAL and EVALUATION
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IMPLANTATION of BIOMATERIALS
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INFLAMMATION, HEALING & BIOMATERIALS Local reaction of vascularized tissue to injury TWO MAIN THEMES: Destruction- or walling off of biomaterial Repair- by normal parenchyma or by scar (fibrosis) TEMPORAL PATTERN ACUTE- short duration, exudative- cells + proteins CHRONIC- long duration, proliferative- cells
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INFLAMMATION and BIOMATERIALS Sequence of Events i Injury I Acute inflammation I Chronic inflammation I Granulation tissue I Foreign body reaction I Fibrosis
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CELLS of INFLAMMATION Differentiation - maturation of stem cells from bone marrow to peripheral blood to tissue Erythrocytic Granulocytic Mononuclear Megakaryocytic Bone Marrow stem cells GROWTH FACTORS/CYTOKINES
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HEMATOPOEISIS TPO EPO INTERLEUKINS INTERLEUKINS CSF CSF
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Eos PMN- seg Baso Mono Lympho Platelet PMN-band
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Other Cells/Components of Inflammation
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LEUKOCYTES in INFLAMMATION Also known as White blood cells Granulocytes- PMNs, Eosinophils, Basophils Monocytes Lymphocytes Mast cells- are tissue cells, not in circulating blood
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LEUKOCYTES in INFLAMMATION Normal value (blood) is 10,000 cells/cubic mm LEUKOCYTOSIS (or –philia) - >10,800/cubic mm, increased numbers LEUKOPENIA - <4,500/cubic mm, decreased PMNs, Monocytes, Lymphocytes and Mast cells are associated with responses to biomaterials
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INFLAMMATORY CELLS & BIOMATERIALS /LYMPHOCYTES Lymphocytes 10 BIOMATERIAL IMPLANT
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INFLAMMATION and BIOMATERIALS Sequence of Events i Injury I Acute inflammation I Chronic inflammation I Granulation tissue I Foreign body reaction I Fibrosis
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ACUTE INFLAMMATION Short duration Hours to a few days I Hemodynamics, Vascular permeability, Leukocyte migration I Exudative or exudates Are protein and cells which bind to biomaterials, “pus” is an exudate
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Calor Rubor Tumor Dolor
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HEMODYNAMICS & INFLAMMATION Starling’s law
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TRANSUDATES vs. EXUDATES
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