EBME 306 LECTURES 6-8-FALL-2008-ZIATS compressed(2)

EBME 306 LECTURES 6-8-FALL-2008-ZIATS compressed(2) -...

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BIOLOGICAL CONSTRAINTS in USING BIOMATERIALS- IMMUNITY & INFECTION Readings for November 12, 14 and 17: Biomaterials: The Intersection of Biology and Materials Science , J.S. Temenoff and A.G. Mikos, Pearson/Prentice Hall, 2008, pp.403-427, 444-455
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Immunity & Biocompatibility I Immunity- response to “foreign”substances organisms materials tissue engineered materials I In fluid ( blood or lymph ) or tissues such as bone marrow, thymus , lymph nodes, spleen I Around materials as part of the chronic inflammatory response
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Immunity I Innate vs . Acquired Immunity: Innate- at birth, phagocytes, complement, immune cells Acquired- exposure, antibodies, B and T cells, complement I Humoral vs. Cell-Mediated Immunity: Humoral- B cells plasma cells antibody Cell-mediated- T cells + Macrophages + B cells + lymphokines
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Immunity-Key Concept I Specificity I Memory I Clonality I Self vs. non-self I Cooperativity I Multicellular and integrated
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Host Defenses in Humans
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Immune System Cells + Soluble molecules Primary immune organs Other immune organs +Complement
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Immune Cells “Education of T cells”
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Eos PMN- seg Baso Mono Lympho Platelet PMN-band
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Immune Cells
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Immunity I Innate vs . Acquired Immunity: Innate- at birth, phagocytes, complement, immune cells Acquired- exposure, antibodies, B and T cells, complement
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Innate and Adaptive Immunity
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Immunity I Humoral vs. Cell-Mediated Immunity: Humoral- B cells plasma cells antibody Cell-mediated- T cells + Macrophages + B cells + lymphokines
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Humoral and Cell-Mediated Immunity
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Antigens and Antibodies
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Antigens I Complex chemicals, often greater than 10,000 M.W., normally not part of the host, molecules that react with antibodies (or T cell receptors). Their name arises from their ability to gen erate anti bodies. I Immunogen - Substance that is capable of inducing an immune response (antibody response or cell- mediated immunity).
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EBME 306 LECTURES 6-8-FALL-2008-ZIATS compressed(2) -...

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