EBME 306 LECTURES 12-13-FALL-2008-ZIATS compressed

EBME 306 LECTURES 12-13-FALL-2008-ZIATS compressed -...

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CARDIOVASCULAR BIOMATERIALS Readings : Biomaterials Science. Eds. Ratner BD et al., 2 nd edition, Academic Press: San Diego, 2004, Ch. 7.3-pp. 470-494
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Vascular Diseases?
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What Is Vascular Disease? Atherosclerosis is the major vascular disease in humans: “Athero” means “Gruel or porridge-like” Medium to large sized vessels An intimal lesion, eccentric
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Atherosclerosis Natural History
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Coronary Artery Disease (CAD) Age 0 10+ 30+ 40+ Key: Stenosis, Focal lesions, Eccentric lesions
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Atherosclerosis SMC Growth, Migration, Synthesis
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Myocardial Infarction (MI) is the Ultimate, Serious Consequence!
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Diagnosis/Treatment of CAD & MI’s Imaging- Doppler scans and angiography Lab tests- cholesterol, LDL/HDL, others Drug therapy- anitcholesterol, antihypertensive Preventative- lifestyle changes Surgical Replacement- CABG or synthetics Surgical Treatment- PTCA and angioplasty Surgical Replacement- Stents
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Atherosclerosis Common Sites of Coronary Angiography
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Vascular Grafts
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Atherosclerosis & Vascular Grafts Common Sites for Grafts Most common Hemodialysis shunts in arm vessels
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Coronary Artery Bypass Grafting (CABG) Autologous vessel is first choice, then synthetic
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Vascular Grafts Polyethylene terephthalate (Dacron™) Used in the 1960’s, mainly used for drapes at time Properties- Hard,stiff, stable and hydrophobic
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