Molecular Imaging handout (Nuclear)

Molecular Imaging handout (Nuclear) - Molecular Imaging The...

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M l l I i Molecular Imaging The Nuclear Medicine Approaches Departments of Biomedical EBME 410/320 Zhenghong Lee Departments of Biomedical Engineering and Radiology Case Western Reserve University Cleveland OH 44106 Cleveland, OH 44106
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Learning Objectives FDG PET imaging & its application in oncology Molecular imaging paradigms – HSV1- tk (suicidal gene used as a reporter gene in imaging) – D2R (Dopamine 2 receptor used as a reporter gene in D2R (Dopamine 2 receptor used as a reporter gene in imaging) Molecular imaging experiments & validations SPECT Imaging & Application Some terms & concepts gene expression (transcription and translation) endogenous genes and transgene reporter/marker genes and its probes enzyme-substrate, receptor-ligand “direct” vs. “indirect” imaging
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