Molecular Imaging handout (Nuclear)

Molecular Imaging handout (Nuclear) - Molecular Imaging The...

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Molecular Imaging The Nuclear Medicine Approaches epartments of Biomedical EBME 410/320 Zhenghong Lee Departments of Biomedical Engineering and Radiology Case Western Reserve University leveland OH 44106 Cleveland, OH 44106
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earning Objectives Learning Objectives • FDG PET imaging & its application in oncology • Molecular imaging paradigms – HSV1- tk (suicidal gene used as a reporter gene in imaging) 2R (Dopamine 2 receptor used as a reporter gene in D2R (Dopamine 2 receptor used as a reporter gene in imaging) • Molecular imaging experiments & validations PECT Imaging & Application SPECT Imaging & Application • Some terms & concepts – gene expression (transcription and translation) – endogenous genes and transgene – reporter/marker genes and its probes – enzyme-substrate, receptor-ligand – “direct” vs. “indirect” imaging
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eferences References • S.S. Gambhir, H.R. Herschman, S.R. Cherry, et al., Imaging ansgene expression with Radionuclide imaging technologies transgene expression with Radionuclide imaging technologies. Neoplasia Vol. 2, Nos. 1-2, p118-138, 2000 • H.R. Herschman, D.C. MacLaren, M. Iyer, et al., Seeing is believing: non-invasive, quantitative and repetive imaging of g ,q p g g reporter gene expression in living animals, using positron emission tomography. Journal of Neuroscince Research 59:699- 705 (2000) Brice Molecular imaging transports diagnosis to the next level J Brice, Molecular imaging transports diagnosis to the next level. Diagnostic Imaging (online) http://www.diagnosticimaging.com/specialeidition/moelular.shtml • M.E. Phelps, Positron emission tomography provides molecular imaging of biological processes. PNAS, Vol. 97, No. 16, p9226- 9233, 2000 • Molecular Imaging. The American College of Radiology, Vol. 56, o 6 p25- 9 2000 No. 6, p25 29, 2000
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Why Molecular Imaging? ost enome era vivo aging Post-genome era, in vivo imaging Functions of the genes, local expression • Define new disease, redefine old disease Treatment & management • Turn nuclear medicine into preventive
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Molecular Imaging handout (Nuclear) - Molecular Imaging The...

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