MRI-3-spectroscopy

MRI-3-spectroscopy - 11/2/2010 NMRSpectroscopy Xin Yu,Sc.D.

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11/2/2010 1 NMR Spectroscopy Xin Yu, Sc.D. Department of Biomedical Engineering Case Western Reserve University EBME410, Xin Yu, Sc.D. Review: Magnetization •P ro ton s in body act like little bar magnets. • Random orientation outside of external Random orientation outside of external magnetic field: no net magnetization. •When placed in magnetic field, they line up to produce net magnetization. Outside of Magnet Inside of Magnet EBME410, Xin Yu, Sc.D. External Magnetic Field
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11/2/2010 2 Review: Resonance •P ro ton s actually wobble around their axis at a specific frequency (dependent on magnetic field strength). •The y can absorb and radiate energy at the Larmor frequency. EBME410, Xin Yu, Sc.D. H + 0 = • B 0 B 0 M 0 180 o 90 o RF TE/2 TE/2 ) ( ) ( 0 / / 0 0 * 2 2 H M e e e M t M t i T t T TE xy ) ( ) ( dt e t M M t i xy xy EBME410, Xin Yu, Sc.D. ) ) ( 1 ) ( ) ( 1 ( 2 0 2 * 2 0 2 * 2 2 0 2 * 2 * 2 / 0 / / 0 0 0 2 0 * 2 2 T T i T T e M dt e e e e M T TE t i t i T t T TE
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11/2/2010 3 / * 2 M T T TE Absorbance Signal 2 0 2 * 2 0 2 ) ( 1 ) ( T e A  * 2 : linewidth - Half T EBME410, Xin Yu, Sc.D. 2 Electron Shielding = •B (1 ) ( 0 B B B : electron shielding factor Solids: orientation dependent, chemical shift tenso = • B 0 (1- ) ) 1 ( 0 0 B B B 0 EBME410, Xin Yu, Sc.D. chemical shift tensor Liquids: anisotropy averaged out due to rapid molecular motion, scalar in liquids B n
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11/2/2010 4 Chemical Shift • Reference: R = B 0 (1 - R ) • Electronic shielding: = B 0 (1 - ) 6 R 10 δ Chemical Shift (ppm): EBME410, Xin Yu, Sc.D. 6 R R 10 δ ) ( Note: Chemical shift is field independent Spectrum Basics •Chem i ca l shift goes in reverse direction •A rea under a given peak (integration) is directly proportional to the number of that type of atom in the molecule EBME410, Xin Yu, Sc.D. ppm Upfield Shielded Downfield De-shielded
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11/2/2010 5 31 P Spectroscopy and the Metabolic Integrity of the Heart EBME410, Xin Yu, Sc.D.
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This note was uploaded on 01/16/2011 for the course EBME 320 taught by Professor Mult during the Fall '10 term at Case Western.

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MRI-3-spectroscopy - 11/2/2010 NMRSpectroscopy Xin Yu,Sc.D.

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