gero310-NutritionAging

gero310-NutritionAging - Gero 310 Fall 2009 Nutrition and...

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Nutrition and Aging Valter Longo` Gero 310 Fall 2009
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Nutrients are available regularly ----> early reproduction, high fecundity, and shorter life span Starvation conditions ----> late reproduction, low fecundity, and longer life span
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Yeast Survival phases Growth (low stress resistance) switch to STATIONARY PHASE -Survival: > 17 days -Low metabolic rates -Stress resistance Expired SDC Medium Water or Rich Medium (YPD) POST-DIAUXIC PHASE -Survival: 6 days -High metabolic rates SPORE -Survival: years -Dormant -Stress Resistance 1 % potassium acetate
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Model for the regulation of the life span extension by the dauer genetic pathway in worms
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Calorie restriction (CR) increases average lifespan in multiple species
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Effect of Caloric Restriction on Body Composition and Organ Weights in Rats
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Caloric restriction increases rodent lifespan at any adult age %survival
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Caloric Restriction in Rodents • 35% life span extension • animal is slightly hungry • Lower blood glucose, insulin and IGF-I • Higher insulin efficiency • Decreased inflammatory responses • Increased resistance to oxidative damage • Lower incidence of tumors, kidney diseases, vascular calcification, chronic pneumonia
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Slows aging in most organs in rodents 1 Slows accelerations of mortality and increases maximum life span in rodents 3 Slows reproductive decline in rodents 2
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inflammatory and oxidative damage changes of aging are attenuated by caloric restriction
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Lee CK. Weindruch R. Prolla TA. Nature Genetics. 25(3):294-7, 2000 Jul. Ageing resulted in a gene-expression profile indicative of an inflammatory response, oxidative stress and reduced neurotrophic support in both brain regions. At the transcriptional level, brain ageing in mice displays parallels with human neurodegenerative disorders”. “Caloric restriction, which retards the ageing
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This note was uploaded on 01/16/2011 for the course GERO 310 taught by Professor Davies during the Fall '09 term at USC.

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gero310-NutritionAging - Gero 310 Fall 2009 Nutrition and...

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