Biol110-10-Lecture 14-Motors - Molecular motors myosin V...

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Molecular motors Reading covered in this lecture: Alberts et al Chapter 16 pgs. 1010-1042 Molecular motors use the polarity of actin filaments or of microtubules and energy from ATP hydrolysis to move directionally along a filament by repeated cycles of conformational changes Motors on microtubules organize membrane bound organelles such as Golgi and mitochondria, and direct vesicular traffic Motors on actin cables are involved in muscle contraction, ciliary beating, cell division myosin V kinesin Reading covered in next lecture: Alberts et al Chapter 17 pgs 1053-1071; 1101-1112; & Chapter 18 pgs 1115-1124
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Molecular motors on actin tracks- The Myosin superfamily ATPase motor (head) tail Myosin II: two heavy chains (two heads), & four light chains that serve as modulators Dozens of other myosin motors in eukaryotes Motors are different in: 1) the cargo and filament they bind to 2) the directionality of movement along a filament 3) Step size (leg length) ATPase
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Direct demonstration that myosin motors (heads) walk along actin cables Immobilized myosin ‘heads’ (S1 fragments) and Phalloidin-labeled actin filaments + ATP
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Myosins walk along the actin filaments by alternating structures - no ATP; rigor state, otherwise short lived ATP binding reduces affinity for actin (dissociation) ATP hydrolysis triggers large
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This note was uploaded on 01/17/2011 for the course BIOL 110 taught by Professor Rexach during the Fall '10 term at University of California, Santa Cruz.

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Biol110-10-Lecture 14-Motors - Molecular motors myosin V...

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