Biol110-10-Problem Set#4

Biol110-10-Problem Set#4 - closed and how do karyopherins...

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Student number__________ Grader number___________ Biol110-Cell Biology Fall 2010 Problem Set #4 Question #1:The Nucleoplasm and Nucleocytoplasmic Trafficking (20 min) What are the two main functions of the nuclear pore complex (NPC) at the nuclear envelope? (4 pts) Structurally, what is the main function of the nucleoporins forming the NPC ring-scaffold? (2 pts) What are the two main functions of the nucleoporins containing FG motifs? (4 pts) According to the hydrogel/selective phase model of NPC architecture, what keeps the conduit gate
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Unformatted text preview: closed and how do karyopherins permeate or open the gate? (5 pts) How can NPCs accommodate karyopherin-cargo complexes of many shapes and sizes during transport while maintaining a sealed permeability barrier against smaller particles? (5 pts) What is the function of Ran in nucleocytoplasmic trafficking? How and where is Ran activated? What is the active form? (5 pts)...
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