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Unformatted text preview: COPII coat subunits? How do COPII vesicles loose their coat in preparation for fusion with the cis-Golgi? (5 pts) Based on the topology of v- and t-SNAREs in the membrane (they have a short lumenal C-terminus), why is it important that v- and t-SNAREs make parallel coiled coil interactions during vesicle fusion? Explain. What would happen if they made anti-parallel interactions? (5 pts) What is the role of NSF and SNAPs in vesicular transport? Why is ATP hydrolysis needed? Why do vesicles accumulate in the absence of NSF activity? (5 pts)...
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- Fall '10