Biol110-10-Problem Set#7

Biol110-10-Problem Set#7 - Why do microtubules depolymerize...

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Student number__________ Grader number___________ Biol110-Cell Biology Fall 2010 Problem Set #7 Question #1- The Cytoskeleton, Its Motors and Muscle Contraction What does the term ‘dynamic instability’ stand for? Explain. Why is dynamic instability enhanced at the onset of mitosis? (5 pts) Why do cells actively nucleate actin and microtubule filaments rather than relying on spontaneous polymer initiation? Where and how is microtubule and actin filament nucleation accomplished at a molecular level? (5 pts)
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Unformatted text preview: Why do microtubules depolymerize more quickly at non-capped ends compared to GTP capped ends? How do catastrophins and gelsolin break microtubule and actin filaments, respectively? What is the common theme in all three cases? (5 pts) What is the functional importance of having very short interaction times between individual actin and myosin molecules during muscle contraction? What happens if rapid dissociation is prevented, and when does this actually occur? (5 pts)...
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